Mapping trends and hotspots regarding clinical research on monkeypox: A bibliometric analysis of global research: Trends and Hotspots on Monkeypox

Zhengyu  Zhang; Yuan  Yuan; Juntao Tan; Yuxi  Zhao; Xiantian  Lin; Jianwen  Ning; Songjia  Tang; Xiaoxin Wu

doi:10.54844/cai.2022.0184

Authors

Zhengyu Zhang Medical Records Department, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Yuan Yuan Medical Department, Women and Children’s Hospital of Chongqing Medical University, Chongqing 401147, China
Juntao Tan Operation management Office, Affiliated Banan Hospital of Chongqing Medical University, Chongqing 401320, China
Yuxi Zhao State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Xiantian Lin State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Jianwen Ning Emergency Department, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Songjia Tang Plastic and Aesthetic Surgery Department, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
Xiaoxin Wu State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China

DOI:

https://doi.org/10.54844/cai.2022.0184

Keywords:

monkeypox virus, bibliometric analysis, research hotspots

Abstract

A large number of papers have been published since the discovery of the monkeypox virus (MPXV). In 2022, human MPXV broke out in the USA and many European countries, and on July 23 of that year, the World Health Organization declared the MPXV outbreak a "Public Health Emergency of International Concern." In this study, we performed bibliometric analysis of MPXV literature published in core journals of the Web of Science core Collection database, which was conducted on 956 articles from 2000 to 2022. We analyzed the publication country, subject category, main authors and institutions, research hotspots of important publications and research frontiers. Through the analysis of keywords co-occurrence, multi-cited literature and co-cited literature, the research hotspots and trends were summarized. This report revealed that MPXV research has focused on hot areas such as infection and vaccination. Since the 2022 human MPXV outbreak, researchers have increasingly focused on infection control, vaccines, and treatment of monkeypox. This article summarizes the research directions and hotspots of MPXV related literature since the 2000, and we hope to provide support and clear research ideas for the future research and prevention of MPXV in humans.

References

Daskalakis D, McClung RP, Mena L, Mermin J. Monkeypox: Avoiding the Mistakes of Past Infectious Disease Epidemics. Ann Intern Med 2022;175:1177–1178. DOI: https://doi.org/10.7326/M22-1748

Lahariya C, Thakur A, Dudeja N. Monkeypox Disease Outbreak (2022): Epidemiology, Challenges, and the Way Forward. Indian pediatr 2022;59:636–642. DOI: https://doi.org/10.1007/s13312-022-2578-2

Guagliardo SAJ, Doshi RH, Reynolds MG, Dzabatou-Babeaux A, Ndakala N, Moses C, et al. Do Monkeypox Exposures Vary by Ethnicity? Comparison of Aka and Bantu Suspected Monkeypox Cases. Am J Trop Med Hyg 2020;102:202–205. DOI: https://doi.org/10.4269/ajtmh.19-0457

Petersen E, Kantele A, Koopmans M, Asogun D, Yinka-Ogunleye A, Ihekweazu C, et al. Human Monkeypox: Epidemiologic and Clinical Characteristics, Diagnosis, and Prevention. Infect Dis Clin North Am 2019;33:1027–1043. DOI: https://doi.org/10.1016/j.idc.2019.03.001

Vivancos R, Anderson C, Blomquist P, Balasegaram S, Bell A, Bishop L, et al. Community transmission of monkeypox in the United Kingdom, April to May 2022. Euro Surveill 2022;27:2200422. DOI: https://doi.org/10.2807/1560-7917.ES.2022.27.22.2200422

Mauldin MR, McCollum AM, Nakazawa YJ, Mandra A, Whitehouse ER, Davidson W, et al. Exportation of Monkeypox virus from the African continent. J Infect Dis 2022;225:1367–1376. DOI: https://doi.org/10.1093/infdis/jiaa559

McCarthy MW. Therapeutic strategies to address monkeypox. Expert Rev Anti Infect Ther 2022;20:1249–1252. DOI: https://doi.org/10.1080/14787210.2022.2113058

Nadar S, Khan T, Omri A. Reemergence of monkeypox: prevention and management. Expert Rev Anti Infect Ther 2022;20:1425–1433. DOI: https://doi.org/10.1080/14787210.2022.2128763

Schnierle BS. Monkeypox Goes North: Ongoing Worldwide Monkeypox Infections in Humans. Viruses 2022;14:1874. DOI: https://doi.org/10.3390/v14091874

Sklenovská N, Van Ranst M. Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans. Front Public Health 2018;6:241. DOI: https://doi.org/10.3389/fpubh.2018.00241

Sale TA, Melski JW, Stratman EJ. Monkeypox: An epidemiologic and clinical comparison of African and US disease. J Am Acad Dermatol 2006;55:478–481. DOI: https://doi.org/10.1016/j.jaad.2006.05.061

Kaler J, Hussain A, Flores G, Kheiri S, Desrosiers D. Monkeypox: A Comprehensive Review of Transmission, Pathogenesis, and Manifestation. Cureus 2022;14:e26531. DOI: https://doi.org/10.7759/cureus.26531

Atkinson B, Burton C, Pottage T, Thompson KA, Ngabo D, Crook A, et al. Infection-competent monkeypox virus contamination identified in domestic settings following an imported case of monkeypox into the UK. Environ Microbiol 2022;24:4561–4569. DOI: https://doi.org/10.1111/1462-2920.16129

Laine C, Moyer DV, Cotton D. Monkeypox: Challenging Clinical Questions. Ann Intern Med 2022. doi: 10.7326/M22-3040. DOI: https://doi.org/10.7326/M22-3040

Al-Musa A, Chou J, LaBere B. The resurgence of a neglected orthopoxvirus: Immunologic and clinical aspects of monkeypox virus infections over the past six decades. Clin Immunol 2022;243:109108. DOI: https://doi.org/10.1016/j.clim.2022.109108

Zhang Y, Zhang JY, Wang FS. Monkeypox outbreak: A novel threat after COVID-19? Military Mil Med Res 2022;9:29. DOI: https://doi.org/10.1186/s40779-022-00395-y

Vaughan AM, Cenciarelli O, Colombe S, Alves de Sousa L, Fischer N, Gossner CM, et al. A large multi-country outbreak of monkeypox across 41 countries in the WHO European Region, 7 March to 23 August 2022. Euro Surveill 2022;27:2200620. DOI: https://doi.org/10.2807/1560-7917.ES.2022.27.36.2200620

World Health Organization. 2022 Monkeypox Outbreak: Global Trends. 2022. Available at: https://worldhealthorg.shinyapps.io/mpx_global/. Accessed on September 18, 2022.

Wang L, Shang J, Weng S, Aliyari SR, Ji C, Cheng G, et al. Genomic Annotation and Molecular Evolution of Monkeypox Virus Outbreak in 2022. J Med Virol 2022. doi: 10.1002/jmv.28036. DOI: https://doi.org/10.1002/jmv.28036

Isidro J, Borges V, Pinto M, Sobral D, Santos JD, Nunes A, et al. Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus. Nat Med 2022;28:1569–1572. DOI: https://doi.org/10.1038/s41591-022-01907-y

Liu X, Zhu Z, He Y, Lim JW, Lane B, Wang H, et al. Monkeypox claims new victims: the outbreak in men who have sex with men. Infect Dis Poverty 2022;11:84. DOI: https://doi.org/10.1186/s40249-022-01007-6

National Health Commission of the People's Republic of China. 2022 Diagnosis and Treatment of Monkeypox. Available at: http://www.nhc.gov.cn/yzygj/s7653p/202206/d687b12fe8b84bbfaede2c7a5ca596ec.shtml. Accessed on September 19, 2022.

Rizk JG, Lippi G, Henry BM, Forthal DN, Rizk Y. Prevention and Treatment of Monkeypox. Drugs 2022;82:957–963. DOI: https://doi.org/10.1007/s40265-022-01742-y

Desai AN, Thompson GR 3rd, Neumeister SM, Arutyunova AM, Trigg K, Cohen SH. Compassionate Use of Tecovirimat for the Treatment of Monkeypox Infection. JAMA 2022;328:1348–1350. DOI: https://doi.org/10.1001/jama.2022.15336

O'Laughlin K, Tobolowsky FA, Elmor R, Overton R, O'Connor SM, Damon IK, et al. Clinical Use of Tecovirimat (Tpoxx) for Treatment of Monkeypox Under an Investigational New Drug Protocol - United States, May-August 2022. MMWR Morb Mortal Wkly Rep 2022;71:1190–1195. DOI: https://doi.org/10.15585/mmwr.mm7137e1

World Health Organization. Monkeypox. 2022. Available at: https://www.who.int/news-room/fact-sheets/detail/monkeypox. Accessed on September 22, 2022.

Yoshikawa T. Third-generation smallpox vaccine strain-based recombinant vaccines for viral hemorrhagic fevers. Vaccine 2021;39:6174–6181. DOI: https://doi.org/10.1016/j.vaccine.2021.09.001

Abdelaal A, Reda A, Lashin BI, Katamesh BE, Brakat AM, AIManaseer BM, et al. Preventing the Next Pandemic: Is Live Vaccine Efficacious against Monkeypox, or Is There a Need for Killed Virus and mRNA Vaccines? Vaccines ( Basel) 2022;10:1419. DOI: https://doi.org/10.3390/vaccines10091419

Rao AK, Petersen BW, Whitehill F, Razeq JH, Isaacs SN, Merchlinsky MJ, et al. Use of JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) for Preexposure Vaccination of Persons at Risk for Occupational Exposure to Orthopoxviruses: Recommendations of the Advisory Committee on Immunization Practices - United States, 2022. MMWR Morb Mortal Wkly Rep 2022;71:734–742. DOI: https://doi.org/10.15585/mmwr.mm7122e1

Aden TA, Blevins P, York SW, Rager S, Balachandran D, Hutson CL, et al. Rapid Diagnostic Testing for Response to the Monkeypox Outbreak - Laboratory Response Network, United States, May 17-June 30, 2022. MMWR Morb Mortal Wkly Rep 2022;71:904–907. DOI: https://doi.org/10.15585/mmwr.mm7128e1

Yuan S, Jiang SC, Zhang ZW, Yang XY, Fu YF, Li ZL, et al. Multiorigins and complex transmission paths of monkeypox viruses. Travel Med Infect Dis 2022;50:102444. DOI: https://doi.org/10.1016/j.tmaid.2022.102444