Innovative treatment methods for skin fungal infections in community

Megha  Verma; Eknath D  Ahire; Anupam  Jaiswal; Muskan  Prajapati; Raj K. Keservani; Rahul R  Sable

doi:10.54844/cai.2023.0149

Authors

Megha Verma
Eknath D Ahire
Anupam Jaiswal
Muskan Prajapati
Raj K. Keservani Associate Professor, Faculty of B. Pharmacy, CSM Group of Institutions, Prayagraj, U.P., India
Rahul R Sable

DOI:

https://doi.org/10.54844/cai.2023.0149

Keywords:

multi-ethosome, terbinafine hydrochloride, cinnamaldehyde, photosensitizer, photodynamic treatment

Abstract

Worldwide, fungus infections of the skin, hair, and nails are a common cause of public health issues. They are, however,
infrequently managed, according to a population-based survey. Skin fungi infections are projected to affect 20%–25% of
people worldwide, and their incidence is rising. They make up 10%–20% of all dermatologic conditions. The goal of this
study was to create and assess a novel multi-ethosome (ME) system for the topical delivery of terbinafine hydrochloride (TH)
as a fresh method for treating fungus infections. Cinnamaldehyde was effectively used as a penetration enhancer to create
TH-loaded MEs. The two-step process of photodynamic treatment (PDT) involves the topical or systemic delivery of a
photosensitizer followed by the selective lighting of the target lesion with visible light, which causes oxidative photodamage
and eventual cell death inside the target area.