The emergence of nanocarriers in the management of diseases and disorders
DOI:
https://doi.org/10.54844/cai.2022.0139Abstract
Drugs can be delivered using oral nanocarriers in controlled, site-specific releases. Target receptors are physically, chemically, and biologically conjugated while administering a specific medicine. Since micro carriers have a 200 nm width, nanomedicine typically refers to objects with that size. Drugs can be delivered by nanocarriers to parts of the body that are inaccessible. Nanocarriers cannot deliver large pharmaceutical dosages due to their small size. Emulsion-based nanocarriers often have poor drug loading and encapsulation, which restricts their potential for therapeutic use. Various therapeutic nanocarriers exist. Ultrabright nanocarriers, polymeric nanocarriers, smart nanocarriers, nanocomposites, protein nanocarriers, nucleic acid-based nanocarriers, carbon nanotubes, and nanobubbles are examples of novel nanocarriers. All of them have successfully treated cancer. This review looks at targeted drug delivery methods and nanocarriers.
References
Dobson J. Gene therapy progress and prospects: magnetic nanoparticlebased gene delivery. Gene Ther. 2006;13(4):283-287.
Zhang L, Gu FX, Chan JM, Wang AZ, Langer RS, Farokhzad OC. Nanoparticles in medicine: therapeutic applications and developments. Clin Pharmacol Ther. 2008;83(5):761-769.
Surendiran A, Sandhiya S, Pradhan SC, Adithan C. Novel applications of nanotechnology in medicine. Indian J Med Res. 2009;130(6):689-701.
Jain KK. Nanodiagnostics: application of nanotechnology in molecular diagnostics. Expert Rev Mol Diagn. 2003;3(2):153-161.
Peng B, Almeqdadi M, Laroche F, et al. Data on ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications. Data Brief. 2019;22:383-391.
Melnychuk N, Klymchenko AS. DNA-functionalized dye-loaded polymeric nanoparticles: ultrabright FRET platform for amplified detection of nucleic acids. J Am Chem Soc. 2018;140(34):10856-10865.
Goetz J, Nonat A, Diallo A, et al. Ultrabright Lanthanide Nanoparticles. Chempluschem. 2016;81(6):497.
Shulov I, Oncul S, Reisch A, et al. Fluorinated counterion-enhanced emission of rhodamine aggregates: ultrabright nanoparticles for bioimaging and light-harvesting. Nanoscale. 2015;7(43):18198-18210.
Sun Y, Cao W, Li S, et al. Ultrabright and multicolorful fluorescence of amphiphilic polyethyleneimine polymer dots for efficiently combined imaging and therapy. Sci Rep. 2013;3:3036.
Bok S, Korampally V, Polo-Parada L, et al. Confeito-like assembly of organosilicate-caged fluorophores: ultrabright suprananoparticles for fluorescence imaging. Nanotechnology. 2012;23(17):175601.
Pieper S, Onafuye H, Mulac D, et al. Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity. Beilstein J Nanotechnol. 2019;10(1):2062-2072.
Shelake SS, Patil SV, Patil SS. Formulation and evaluation of fenofibrateloaded nanoparticles by precipitation method. Indian J Pharm Sci. 2018;80(3):420-427.
Patel A, Khanna S, Xavier GK, Khanna K, Goel B. Polymeric NanoParticles for Tumor Targeting – A Review. Int J Drug Dev & Res. 2017;9:50-59.
Bohrey S, Chourasiya V, Pandey A. Polymeric nanoparticles containing diazepam: preparation, optimization, characterization, in-vitro drug release and release kinetic study. Nano Converg. 2016;3(1):3.
Solar P, González G, Vilos C, et al. Multifunctional polymeric nanoparticles doubly loaded with SPION and ceftiofur retain their physical and biological properties. J Nanobiotechnology. 2015;13:14.
Tharkar P, Varanasi R, Wong WSF, Jin CT, Chrzanowski W. Nanoenhanced drug delivery and therapeutic ultrasound for cancer treatment and beyond. Front Bioeng Biotechnol. 2019;7:324.
Baghirov H, Snipstad S, Sulheim E, et al. Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model. PLoS One. 2018;13(1):e0191102.
Paris JL, Mannaris C, Cabañas MV, et al. Ultrasound-mediated cavitationenhanced extravasation of mesoporous silica nanoparticles for controlled-release drug delivery. Chem Eng J. 2018;340:2-8.
McClure A. Using high-intensity focused ultrasound as a means to provide targeted drug delivery. J Diagn Med Sonogr. 2016;32(6):343-350.
Zhou QL, Chen ZY, Wang YX, Yang F, Lin Y, Liao YY. Ultrasoundmediated local drug and gene delivery using nanocarriers. Biomed Res Int. 2014;2014:963891.
Li C, Yang XQ, An J, et al. A near-infrared light-controlled smart nanocarrier with reversible polypeptide-engineered valve for targeted fluorescence-photoacoustic bimodal imaging-guided chemophotothermal therapy. Theranostics. 2019;9(25):7666-7679.
Moradi F, Parsaie H, Gorgich EA. Targeted delivery of therapeutic agents by smart nanocarrier for treatment of parkinson’s disease: a novel brain targeting approach. Gene, Cell Tissue. 2019;6(2):e91213.
Hossen S, Hossain MK, Basher MK, Mia MNH, Rahman MT, Uddin MJ. Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: a review. J Adv Res. 2019;15:1-18.
Cui W, Li J, Decher G. Self-assembled smart nanocarriers for targeted drug delivery. Adv Mater. 2016;28(6):1302-1311.
Choi KY, Yoon HY, Kim JH, et al. Smart nanocarrier based on PEGylated hyaluronic acid for cancer therapy. ACS Nano. 2011;5(11):8591-8599.
Shabatina TI, Vernaya OI, Shabatin VP, Melnikov MY, Semenov AM, Lozinsky VI. Metal nanoparticle containing nanocomposites of drug substances and their potential biomedical applications. Appl Sci. 2019;10(1):170.
Sharma G, Naushad M, Thakur B, et al. Sodium dodecyl sulphatesupported nanocomposite as drug carrier system for controlled delivery of ondansetron. Int J Environ Res Public Health. 2018;15(3):414.
Ghaderi-Ghahfarrokhi M, Haddadi-Asl V, Zargarian SS. Fabrication and characterization of polymer-ceramic nanocomposites containing drug loaded modified halloysite nanotubes. J Biomed Mater Res A. 2018;106(5):1276-1287.
Jafarbeglou M, Abdouss M, Shoushtari AM, Jafarbeglou M. Clay nanocomposites as engineered drug delivery systems. RSC Adv. 2016;6(55):50002-50016.
Berber MR, Hafez IH, Minagawa K, Mori T, Tanaka M. Versatile nanocomposite formulation system of non-steroidal anti-inflammatory drugs of the arylalkanoic acids. In: Abbass Hashim, eds. Advances in Nanocomposite Technology. Intech; 2011.
Wu J, Kamaly N, Shi J, et al. Development of multinuclear polymeric nanoparticles as robust protein nanocarriers. Angew Chem Int Ed Engl. 2014;53(34):8975-8979.
Mattu C, Li R, Ciardelli G. Chitosan nanoparticles as therapeutic protein nanocarriers: the effect of ph on particle formation and encapsulation efficiency. Polym Compos. 2013;34(9):1538-1545.
Lee Y, Ishii T, Cabral H, et al. Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm. Angew Chem Int Ed Engl. 2009;48(29):5309-5312.
Hanafy NAN, Quarta A, Di Corato R, et al. Hybrid polymeric-protein nano-carriers (HPPNC) for targeted delivery of TGFβ inhibitors to hepatocellular carcinoma cells. J Mater Sci Mater Med. 2017;28(8):120.
Kang B, Okwieka P, Schöttler S, et al. Carbohydrate-based nanocarriers exhibiting specific cell targeting with minimum influence from the protein Corona. Angew Chem Int Ed Engl. 2015;54(25):7436-7440.
Chen WH, Liao WC, Sohn YS, et al. Stimuli-responsive nucleic acidbased polyacrylamide hydrogel-coated metal-organic framework nanoparticles for controlled drug release. Adv Funct Mater. 2018;28(8):1705137.
Almalik A, Day PJ, Tirelli N. HA-coated chitosan nanoparticles for CD44-mediated nucleic acid delivery. Macromol Biosci. 2013;13(12):1671-1680.
Gill R, Polsky R, Willner I. Pt nanoparticles functionalized with nucleic acid act as catalytic labels for the chemiluminescent detection of DNA and proteins. Small. 2006;2(8/9):1037-1041.
Li W, Szoka FC Jr. Lipid-based nanoparticles for nucleic acid delivery. Pharm Res. 2007;24(3):438-449.
Lee H, Lytton-Jean AKR, Chen Y, et al. Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Nat Nanotechnol. 2012;7(6):389-393.
Mohseni-Dargah M, Akbari-Birgani S, Madadi Z, Saghatchi F, Kaboudin B. Carbon nanotube-delivered iC9 suicide gene therapy for killing breast cancer cells in vitro. Nanomedicine (Lond). 2019;14(8):1033-1047.
Pardo J, Peng Z, Leblanc RM. Cancer targeting and drug delivery using carbon-based quantum dots and nanotubes. Molecules. 2018;23(2):378.
Abbaspour A, Izadyar A. Carbon nanotube composite coated platinum electrode for detection of Cr(III) in real samples. Talanta. 2007;71(2):887-892.
Dumortier H, Lacotte S, Pastorin G, et al. Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells. Nano Lett. 2006;6(7):1522-1528.
Guo J, Zhang X, Li Q, Li W. Biodistribution of functionalized multiwall carbon nanotubes in mice. Nucl Med Biol. 2007;34(5):579-583.
Shanmugam S, Baskaran R, Balakrishnan P, Thapa P, Yong CS, Yoo BK. Solid self-nanoemulsifying drug delivery system (S-SNEDDS) containing phosphatidylcholine for enhanced bioavailability of highly lipophilic bioactive carotenoid lutein. Eur J Pharm Biopharm. 2011;79(2):250-257.
Friedl H, Dünnhaupt S, Hintzen F, et al. Development and evaluation of a novel mucus diffusion test system approved by self-nanoemulsifying drug delivery systems. J Pharm Sci. 2013;102(12):4406-4413.
Fahmy UA, Ahmed OAA, Hosny KM. Development and evaluation of avanafil self-nanoemulsifying drug delivery system with rapid onset of action and enhanced bioavailability. AAPS PharmSciTech. 2015;16(1):53-58.
Shakeel F, Iqbal M, Ezzeldin E. Bioavailability enhancement and pharmacokinetic profile of an anticancer drug ibrutinib by selfnanoemulsifying drug delivery system. J Pharm Pharmacol. 2016;68(6):772-780.
Shakeel F, Haq N, Alanazi FK, Alsarra IA. Polymeric solid selfnanoemulsifying drug delivery system of glibenclamide using coffee husk as a low cost biosorbent. Powder Technol. 2014;256:352-360.
Ahire ED, Kshirsagar SJ. Efflux Pump Inhibitors: New Hope in Microbial Multidrug Resistance: Role of Efflux Pump Inhibitors in multidrug resistance protein (P-gp). Community Acquir Infect. 2022;9:3.
Song W, Luo Y, Zhao Y, et al. Magnetic nanobubbles with potential for targeted drug delivery and trimodal imaging in breast cancer: an in vitro study. Nanomedicine (Lond). 2017;12(9):991-1009.
Marano F, Argenziano M, Frairia R, et al. Doxorubicin-loaded nanobubbles combined with extracorporeal shock waves: basis for a new drug delivery tool in anaplastic thyroid cancer. Thyroid. 2016;26(5):705-716.
Deng L, Li L, Yang H, et al. Development and optimization of doxorubicin loaded poly(lactic-co-glycolic acid) nanobubbles for drug delivery into HeLa cells. J Nanosci Nanotechnol. 2014;14(4):2947-2954.
Zhou X, Guo L, Shi D, Duan S, Li J. Biocompatible chitosan nanobubbles for ultrasound-mediated targeted delivery of doxorubicin. Nanoscale Res Lett. 2019;14(1):24.
Ahire E, Thakkar S, Darshanwad M, Misra M. Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications. Acta Pharm Sin B. 2018;8(5):733-755.
Kim OY, Choi SJ, Jang SC, et al. Bacterial protoplast-derived nanovesicles as vaccine delivery system against bacterial infection. Nano Lett. 2015;15(1):266-274.
Ahire E, Thakkar S, Borade Y, Misra M. Nanocrystal based orally disintegrating tablets as a tool to improve dissolution rate of Vortioxetine. Bull Fac Pharm Cairo Univ. 2021;58:11–20.
Yu M, Song W, Tian F, et al. Temperature- and rigidity-mediated rapid transport of lipid nanovesicles in hydrogels. Proc Natl Acad Sci U S A. 2019;116(12):5362-5369.
Ahire ED, Talele SG, Shah HS. Nanoparticles as a promising technology in microbial pharmaceutics. In: Mahapatra DK, Talele SG, Haghi, eds. Applied Pharmaceutical Science and Microbiology. Apple Academic Press; 2020: 133-158.
Pinilla CMB, Brandelli A. Antimicrobial activity of nanoliposomes coencapsulating nisin and garlic extract against Gram-positive and Gramnegative bacteria in milk. Innov Food Sci Emerg Technol. 2016;36:287-293.
Ahirrao SP, Sonawane MP, Bhambere DS, et al. Cocrystal formulation: a novel approach to enhance solubility and dissolution of etodolac. Biosci, Biotech Res Asia. 2022;19(1):111-119.
Kim SQ, Kim KH. Emergence of edible plant-derived nanovesicles as functional food components and nanocarriers for therapeutics delivery: potentials in human health and disease. Cells. 2022;11(14):2232.
Rosa P, Stigliano E, Poltronieri P. Foresight on nanovesicles in plantpathogen interactions. In: Poltronieri P, Hong YG, eds. Applied Plant Biotechnology for Improving Resistance to Biotic Stress. Elsevier; 2020: 307-319.
Kim OY, Choi SJ, Jang SC, et al. Bacterial protoplast-derived nanovesicles as vaccine delivery system against bacterial infection. Nano Lett. 2015;15(1):266-274.
Yu M, Song W, Tian F, et al. Temperature- and rigidity-mediated rapid transport of lipid nanovesicles in hydrogels. Proc Natl Acad Sci U S A. 2019;116(12):5362-5369.
Tarn D, Ashley CE, Xue M, Carnes EC, Zink JI, Brinker CJ. Mesoporous silica nanoparticle nanocarriers: biofunctionality and biocompatibility. Acc Chem Res. 2013;46(3):792-801.
Hossen S, Hossain MK, Basher MK, Mia MNH, Rahman MT, Uddin MJ. Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: a review. J Adv Res. 2019;15:1-18.
Kiew SF, Kiew LV, Lee HB, Imae T, Chung LY. Assessing biocompatibility of graphene oxide-based nanocarriers: a review. J Control Release. 2016;226:217-228.
Reddy LH, Arias JL, Nicolas J, Couvreur P. Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications. Chem Rev. 2012;112(11):5818-5878.
Ahire ED, Sharma N, Gupta PC, et al. Developing Formulations of Prebiotics and Probiotics. In: Kesharwani RK, Rao TJM, Keservani RK, eds. Prebiotics and Probiotics in Disease Regulation and Management. Scrivener Publishing; 2022: 271-290.
Parveen K, Banse V, Ledwani L. Green synthesis of nanoparticles: their advantages and disadvantages. AIP Conf Proc. 2016;1724(1):020048.
Rout GK, Shin HS, Gouda S, et al. Current advances in nanocarriers for biomedical research and their applications. Artif Cells Nanomed Biotechnol. 2018;46(sup2):1053-1062.
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