The relationship of depression, gut microbiota and colorectal cancer: A negative cycle

Xiaohe Sun; Yiran Li; Wei Li; Sheyida Koeban; Luzhen Zhang; Weilin Zhang; Xijie Li; Yanman Zhang; Liejian Li; Hao Chen; Feiyang Tang; Tianyu Li

doi:10.54844/wsr.2025.0910

Authors

Xiaohe Sun GuangDong Medical University
Yiran Li
Wei Li
Sheyida Koeban
Luzhen Zhang
Weilin Zhang
Xijie Li
Yanman Zhang
Liejian Li
Hao Chen
Feiyang Tang
Tianyu Li

DOI:

https://doi.org/10.54844/wsr.2025.0910

Abstract

It has been reported that gut microbiota play an important role in the development of colorectal cancer (CRC), and emerging evidence suggests that disturbances in the gut microbiome may also impact the central nervous system through the microbiome-gut-brain axis (MGBA). This review aimed to explore the potential connections between CRC, depression, and gut microbiota, in order to identify new clinical strategies for alleviating depressive symptoms. We utilized data from the 2005–2016 Continuous National Health and Nutrition Examination Survey (NHANES) provided by the Centers for Disease Control and Prevention (CDC), specifically using the Depression Screener Questionnaire (DPQ), which includes nine items scored from "0" (not at all) to "3" (nearly every day). We extracted the proportion of CRC patients who scored "3" on each item and calculated their percentage relative to the total number of participants for each year. This analysis generated bar graphs and tables summarizing the prevalence of depressive symptoms. Results showed that the most frequently reported symptoms were related to neurological dysfunction, such as persistent fatigue and abnormal sleep patterns, which indirectly support the existence of gut-brain interactions. In conclusion, our findings highlight a potential link between intestinal microbiota imbalance, CRC, and depression, suggesting that the gut microbiome may play a significant role in the onset or progression of depression and could serve as a novel target for the treatment of mental health disorders.

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