Platelet metabolic remodeling in thrombosis

Authors

  • Min Fei Department of Cardiology, Shengli Clinical Medical College of Fujian Medical University
  • Yansong Guo Department of Cardiology, Shengli Clinical Medical College of Fujian Medical University
  • Huiqing Wang The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University
  • Nan Lin Department of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital

DOI:

https://doi.org/10.54844/mtm.2023.0422

Keywords:

thrombosis, platelets, glycolysis, fatty acid metabolism, amino acid metabolism

Abstract

Many human diseases are associated with hyperactivity of platelet metabolism. Understanding in detail the connection between metabolic changes and platelet activation state is an indispensable part of thrombosis treatment. This review describes changes in the energy metabolism of platelets during thrombosis and their potential molecular mechanisms. The metabolic flexibility of energy substrate selection in activated platelets is discussed briefly, along with strategies by which platelet activation and thrombosis formation can be blocked by targeting activated platelet metabolism.

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Published

2023-12-27

How to Cite

1.
Fei M, Guo Y, Wang H, Lin N. Platelet metabolic remodeling in thrombosis. Metabol Transl Med. 2023;1. doi:10.54844/mtm.2023.0422

Issue

Vol. 1 (2023)

Section

Review Article

License

Copyright (c) 2023 Min Fei, Yansong Guo, Huiqing Wang, Nan Lin

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.