Community Acquired Infection https://test.hksmp.com/journals/cai <p>Community Acquired Infection, a publication of Scholar Media Publishing Co. Ltd (SMP), is a peer-reviewed online journal with continuous publishing. The journal’s full text is available online at http://www.caijournal.com. The journal allows free access (Open Access) to its contents and permits authors to self-archive the final accepted version of their articles on any OAI-compliant institutional or subject-based repository, a practice it has maintained since becoming a fully open access publication in 2014. The journal does not charge for submission, processing or publication of manuscripts and even for color reproduction of photographs.</p> Scholar Media Publishing en-US Community Acquired Infection 2225-6482 Cerebral Aspergillus abscess in an immunecompetent patient: A case report https://test.hksmp.com/journals/cai/article/view/1112 <div> <p><span lang="EN-US">Central nervous system (CNS) aspergillosis is a rare and highly fatal fungal disease, usually occurring in immunocompromised patients, with delayed diagnosis and difficult treatment. We describe a case of cerebral aspergillus abscess in a patient without apparent <a name="OLE_LINK4"></a>immunodeficiency. A 76-year-old man presented with progressive headache, fever, and lethargy for 2 months. Cranial CT showed abscesses in the left frontal, temporal, and parietal lobes and lateral ventricles, and chronic inflammation in the bilateral maxillary sinuses, left ethmoid sinus, and sphenoid sinus. Sphenoid sinus tissue revealed <em>Aspergillus fumigatus</em> on direct smear, culture, and histopathology. Voriconazole therapy was initiated immediately. Subsequent removal of multiple intracranial abscesses also confirmed <em>A fumigat</em>us.&nbsp;</span><span lang="EN-US">As one of the few reported cases of cerebral aspergillus abscess in an immunocompetent patient who achieved a favorable outcome after complete surgical resection and voriconazole therapy, this case offers new insights and proposes a framework for surveillance and clinical management. It underscores that aspergillus may invade the brain via the paranasal sinuses, and that early diagnosis together with urgent surgical intervention and antifungal therapy is crucial for reducing mortality.</span></p> </div> Yi Jin Hua Zhang Yuansu Jiang Daohong Zhou Copyright (c) 2026 Yi Jin, Hua Zhang, Yuansu Jiang, Daohong Zhou https://creativecommons.org/licenses/by-nc-sa/4.0 2026-03-06 2026-03-06 13 10.54844/cai.2025.1112