Risk factors of recurrence and pregnancy in patients with borderline ovarian tumors: A retrospective study with 16-year follow-up

Abstract

Background: This study aimed to analyze the risk factors that affect recurrence in patients with borderline ovarian tumors （BOTs） after radical surgery and the risk factors that influence recurrence and pregnancy in patients after fertility-sparing surgery (FSS).

Methods: This retrospective cohort study collected data from clinical records of patients in the Beijing Chaoyang Hospital affiliated to Capital Medical University from January 2005 to November 2021. Clinicopathological and surgical variables were analyzed using univariate analyses and survival curves.

Results: 169 BOT patients were included in this study, with a median age of 45 years and a median follow-up time of 81months. Among these patients, 21 had relapsed. Of the 60 patients who received FSS, 16 attempted to conceive, and 13 successfully conceived spontaneously. In univariate analyses, FIGO stage and invasive implantation were risk factors for recurrence of BOTs. After multivariate analysis, FIGO stage was the only identified risk factor. Tumor site was risk factor for recurrence of BOTs receiving FSS. No risk factors for pregnancy in BOTs receiving FSS were found.

Conclusion: After univariate analysis and multivariate analysis, we identified some risk factors for recurrence after radical surgery or FSS, but they did not affect the overall survival rate and pregnancy rate. Laparoscopy procedures are recommended, and chemotherapy is not recommended for patients receiving FSS. We suggest that patients who preserve fertility should try to conceive as soon as possible and follow up closely.